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Find The Scoop On The XMU-MP-1 Before You Are Too Late
After the removal of baseline lesions, any colorectal adenoma detected at colonoscopy at least 6 months after randomization into either trial was counted as a recurrent adenoma. Adenomas were classified as advanced if they had a diameter of 1 cm or more, and/or tubulovillous or villous histology (at least 25% villous). Additionally, adenocarcinomas (n?=?12) were counted as advanced recurrences. All other adenomas were considered nonadvanced. In subjects with more than one adenoma, size and characterization of the histologic type were based on the largest and/or most advanced adenoma. Measurement of 25(OH)D concentrations was performed at Heartland Assays (Ames, IA) using ALPI a competitive chemiluminescence immunoassay.[23] click here The laboratory utilized several QA/QC measures, including a pooled serum sample analyzed with batches of study samples to monitor analytical precision and identify possible laboratory shifts over time, as well as testing duplicates in different batches. The coefficient of variation was <7.0% for 25(OH)D analyses. All analyses were conducted in a blinded fashion. Participants were categorized by circulating concentrations of 25(OH)D into one of the three categories: insufficient (<20 ng/mL), suboptimal (��20 and <30 ng/mL) and optimal (��30 ng/mL).[24, 25] Descriptive data for baseline characteristics by study and by category of 25(OH)D concentration were calculated with means PKC412 and standard deviations for the continuous variables and frequencies and percentages for the categorical variables. Unconditional logistic regression modeling was used to evaluate the associations between 25(OH)D concentrations and baseline adenoma characteristics, as well as for the relationship between 25(OH)D and adenoma recurrence. Variables assessed for potential confounding in both models were season of blood draw, intervention group, age, body mass index (BMI), gender, race, family history of colorectal cancer, current smoking, history of previous polyps and aspirin use; dietary intake of fat, fiber, folate, magnesium, and calcium, supplement use, and energy intake. If a variable changed the point estimate by 10% or greater, it was included in the final multivariate logistic regression analyses of 25(OH)D and baseline adenoma characteristics and recurrence. The variables that met this criterion were BMI, gender, age, race and study and as such they were included in the final models. Data were complete for all variables with the exception of that for previous polyps; participants missing these data were dropped from the descriptive data summarized in Tables 1 and 2. A variable accounting for study (WBF vs. UDCA) was added to the final model to account for any potential differences between the two populations.
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